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Autophagy Regulation of Metabolism Is Required for CD8

Authors :
Lindsay, DeVorkin
Nils, Pavey
Gillian, Carleton
Alexandra, Comber
Cally, Ho
Junghyun, Lim
Erin, McNamara
Haochu, Huang
Paul, Kim
Lauren G, Zacharias
Noboru, Mizushima
Tatsuya, Saitoh
Shizuo, Akira
Wayne, Beckham
Alireza, Lorzadeh
Michelle, Moksa
Qi, Cao
Aditya, Murthy
Martin, Hirst
Ralph J, DeBerardinis
Julian J, Lum
Source :
Cell reports. 27(2)
Publication Year :
2018

Abstract

Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in the regulation of CD8

Details

ISSN :
22111247
Volume :
27
Issue :
2
Database :
OpenAIRE
Journal :
Cell reports
Accession number :
edsair.pmid..........9a569c483309c526ba1ba7fa7a02a400