Back to Search Start Over

Organ-specific differences in 8-oxoguanosine glycosylase (OGG1) repair following acute treatment with benzo[a]pyrene

Authors :
T, Stedeford
F, Cardozo-Pelaez
C, Hover
R D, Harbison
J, Sanchez-Ramos
Source :
Research communications in molecular pathology and pharmacology. 109(1-2)
Publication Year :
2001

Abstract

The lung has been shown to be a target organ for the deleterious effects of Benzo[a]pyrene (B[a]P), regardless of the route of exposure. 8-hydroxy-2'-deoxyguanosine (oxo8dG) is a mutagenic lesion formed in DNA following exposure to B[a]P. The objective of this study was to determine the capacity of different organs to repair oxo8dG following intraperitoneal (i.p.) treatment with B[a]P. Male Spraque-Dawley rats were administered 20 mg/kg B[a]P i.p., 2 times/day for 5 days. A 26% decrease in the capacity to remove oxo8dG was observed in lung tissue at 72 hours and recovered 20% above control values at 120 hours. The capacity of the liver and kidney remained at baseline for all time points analyzed. A 7-fold increase in oxo8dG was observed in the lung at 72 hours. This study demonstrates that organ-specific differences exist in the capacity to remove oxo8dG and further demonstrates the susceptibility of lung tissue to the effects of B[a]P.

Details

ISSN :
10780297
Volume :
109
Issue :
1-2
Database :
OpenAIRE
Journal :
Research communications in molecular pathology and pharmacology
Accession number :
edsair.pmid..........9818015ccfefda17a58ab96efe208127