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The role of biophysical stimulation with pemfs in fracture healing: from bench to bedside
- Source :
- Journal of biological regulators and homeostatic agents. 34(5 Suppl. 1)
- Publication Year :
- 2021
-
Abstract
- Clinical biophysics investigates the relationship between non-ionizing physical energy and the human body. This narrative review aims to summarize the current evidence on the efficacy of PEMF-therapy in the promotion of fracture healing. The effectiveness of PEMFs has been deeply investigated in preclinical in vitro ed in vivo studies and level-I clinical studies. All these studies depicted only PEMF-devices with specific physical wave features - i.e. pulse shape, frequency and amplitude- could significantly promote bone repair. Moreover, the dose-response relationship was also defined in preclinical studies, thus providing the minimum exposure time needed in PEMF-therapy. PEMFs are currently employed in the management several bone injuries, including acute fractures at non-union risk, non-unions, osteotomies, stress fractures and osteonecrosis. Moreover, several ongoing studies are investigating the effectiveness of PEMFs on emerging clinical conditions, thus the indications to PEMF-therapy could potentially raise in future years.
Details
- ISSN :
- 0393974X
- Volume :
- 34
- Issue :
- 5 Suppl. 1
- Database :
- OpenAIRE
- Journal :
- Journal of biological regulators and homeostatic agents
- Accession number :
- edsair.pmid..........96b573851cac7aa34113e392cc89edf4