Back to Search
Start Over
Changes in hemostatic factors after kidney transplantation
- Source :
- Medicine
- Publication Year :
- 2021
- Publisher :
- Lippincott Williams & Wilkins, 2021.
-
Abstract
- Chronic kidney disease affects hemostasis in complex ways, producing both thrombotic and hemorrhagic diatheses. These changes may impact patient morbidity and mortality pre-transplantation, as well as allograft survival after kidney transplantation (KT). This study was conducted to analyze changes in hemostatic factors in the early post-KT period. We retrospectively analyzed 676 recipients of kidney allografts from December 2009 to December 2014. Patients receiving plasmapheresis pre- or post-KT, experiencing early allograft failure, or receiving anticoagulants or antiplatelet agents pre- or post-KT were excluded. Of the 367 included patients, acute (≤1 month) rejection occurred in 4.1% and delayed graft function occurred in 3.3%. Postoperative bleeding complications occurred in 7.9% of patients and thrombotic complications in 3.3%. Pre-transplantation, recipients had below normal hemoglobin, above normal d-dimer and homocysteine levels, and elevated rates of antiphospholipid antibodies. Hemoglobin increased to almost normal by postoperative day (POD) 28 (P
- Subjects :
- hemostatic factors
Adult
Graft Rejection
Male
Observational Study
kidney transplantation
Middle Aged
Hemostatics
Cohort Studies
Postoperative Complications
Republic of Korea
Electronic Health Records
Humans
Kidney Failure, Chronic
Female
end stage renal disease
chronic kidney disease
Research Article
Retrospective Studies
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 100
- Issue :
- 36
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.pmid..........944ec01dc0f15a8bf993256f292ea6d0