Plasma microRNA signature in presymptomatic and symptomatic subjects with

To identify potential biomarkers of preclinical and clinical progression in chromosome 9 open reading frame 72 gene (The PREV-DEMALS study is a prospective study including 22Four miRNAs were differentially expressed between patients and controls: miR-34a-5p and miR-345-5p were overexpressed, while miR-200c-3p and miR-10a-3p were underexpressed in patients. MiR-34a-5p was also overexpressed in presymptomatic carriers compared with healthy controls, suggesting that miR-34a-5p expression is deregulated in cases withWe identified a signature of four miRNAs differentially expressed in plasma between clinical conditions that have potential to represent progression biomarkers forNCT02590276.