[Stretch-induced axon growth: a universal, yet poorly explored process]

The growth of axons is a key step in neuronal circuit assembly. The axon starts elongating with the migration of its growth cone in response to molecular signals present in the surrounding embryonic tissues. Following the formation of a synapse between the axon and the target cell, the distance which separates the cell body from the synapse continues to increase to accommodate the growth of the organism. This second phase of elongation, which is universal and crucial since it contributes to an important proportion of the final axon size, has been historically referred to as "stretch-induced axon growth". It is indeed likely to result from a mechanical tension generated by the growth of the body, but the underlying mechanisms remain poorly characterized. This article reviews the experimental studies of this process, mainly analysed on cultured neurons so far. The recent development of in vivo imaging techniques and tools to probe and perturb mechanical forces within embryos will shed new light on this universal mode of axonal growth. This knowledge may inspire the design of novel tissue engineering strategies dedicated to brain and spinal cord repair.