T-Type Calcium Channels as Potential Therapeutic Targets in Vemurafenib-Resistant BRAF

Authors :: Carla, Barceló
Pol, Sisó
Oscar, Maiques
Sandra, García-Mulero
Rebeca, Sanz-Pamplona
Raúl, Navaridas
Cristina, Megino
Isidre, Felip
Izaskun, Urdanibia
Núria, Eritja
Xavier, Soria
Josep M, Piulats
Rosa M, Penin
Xavier, Dolcet
Xavier, Matías-Guiu
Rosa M, Martí
Anna, Macià
Source :: The Journal of investigative dermatology. 140(6)
Publication Year :: 2019
Abstract: Melanoma is a malignant neoplasia that is highly resistant to chemotherapy and radiotherapy and is associated with poor prognosis in advanced stage. Targeting melanoma that harbors the common BRAF

Subjects :: Proto-Oncogene Proteins B-raf
Skin Neoplasms
Calcium Channel Blockers
Xenograft Model Antitumor Assays
Calcium Channels, T-Type
Mice
Vemurafenib
Drug Resistance, Neoplasm
Cell Line, Tumor
Antineoplastic Combined Chemotherapy Protocols
Animals
Humans
Melanoma
Protein Kinase Inhibitors

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