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Decreased synapse-associated proteins are associated with the onset of epileptic memory impairment in endothelial
- Source :
- MedComm. 3(3)
- Publication Year :
- 2021
-
Abstract
- Accumulating evidence indicates that epilepsy has a higher risk of inducing memory impairment and dementia. However, the underlying onset mechanism remains unclear. Here, we found that mice with spontaneous epilepsy induced by endothelial CDK5 deficiency exhibited hippocampal-dependent memory impairment at 6 months of age, but not at 2 months of age. Moreover, the persistent epileptic seizures induce aberrant changes in phosphorylation of CaMKII protein in the hippocampus of spontaneous epileptic mice. Using genome-wide RNA sequencing and intergenic interaction analysis of STRING, we found that in addition to epilepsy-related genes, there are changes in synaptic organization pathway node genes, such as
Details
- ISSN :
- 26882663
- Volume :
- 3
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- MedComm
- Accession number :
- edsair.pmid..........90ae32de5fd80c365fde357a8c3b58fc