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A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia
- Source :
- Bosnian journal of basic medical sciences. 22(4)
- Publication Year :
- 2021
-
Abstract
- Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic significance and functions of ferroptosis-related genes (FRGs) in AML have not received sufficient attention. The aim of this article was to evaluate the association between FRGs levels and AML prognosis using publicly available RNA-sequencing datasets. The univariate Cox regression analysis identified 20 FRGs that correlate with patient overall survival. The LASSO Cox regression model was used to construct a prognostic 12-gene risk model using a TCGA cohort, and internal and external validation proved the signature efficient. The 12-FRGs signature was then used to assign patients into high- and low-risk groups, with the former exhibiting markedly reduced overall survival, compared to the low-risk group. ROC curve analysis verified the predictive ability of the risk model. Functional analysis showed that immune status and drug sensitivity differed between the 2 risk groups. In summary, FRGs is a promising candidate biomarker and therapeutic target for AML.
Details
- ISSN :
- 18404812
- Volume :
- 22
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Bosnian journal of basic medical sciences
- Accession number :
- edsair.pmid..........8e918fd6a9f421ccf0a6506f604e7827