Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine

Authors :: Jing, Li
Daniëlle, Copmans
Michèle, Partoens
Borbála, Hunyadi
Walter, Luyten
Peter, de Witte
Source :: ACS chemical neuroscience. 11(5)
Publication Year :: 2020
Abstract: With the aim to discover interesting lead compounds that could be further developed into compounds active against pharmacoresistant epilepsies, we first collected 14 medicinal plants used in traditional Chinese medicine (TCM) against epilepsy. Of the six extracts that tested positive in a pentylenetetrazole (PTZ) behavioral zebrafish model, only the ethanol and acetone extracts from

Subjects :: Mice
Epilepsy
Magnolia
Plant Extracts
Biphenyl Compounds
Animals
Anticonvulsants
Medicine, Chinese Traditional
Lignans
Zebrafish

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