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[Transitional cell carcinoma of the upper urinary tract new concepts in management]
- Source :
- Presse medicale (Paris, France : 1983). 34(8)
- Publication Year :
- 2005
-
Abstract
- Transitional cell carcinomas of the upper urinary tract (UUT-TCCs) are rare: they account for approximately 5% of all urothelial carcinomas. 30% of patients with UUT-TCC have a history of bladder TCC, but fewer than 2% of patients with bladder TCC have UUT-TCC. Tumor microsatellite instability (MSI) is an indicator of the clonal expansion of neoplasms; it was first identified in tumors from patients with hereditary non-polyposis colorectal carcinoma (HNPCC). UUT-TCC occurs in 5% of patients with HNPCC. High-frequency microsatellite instability is present in almost 20% of cases of sporadic UUT-TCC. In cases of UUT-TCC with high-frequency MSI, hereditary cancer must be sought, especially if the patient is younger than 60 years or has a personal or family history of an HNPCC-related cancer: such patients should undergo DNA sequencing for the MSH2 gene germline mutation. Invasive UUT-TCC has a poor prognosis. 5-year survival is less than 50% for stage T2-T3 tumors and less than 10% for T4 or N+/M+ tumors. The main prognostic factors are age and tumor stage and grade. High-frequency MSI is a positive prognostic factor, especially in patients younger than 70 years with T2/T3/N0-M0 tumors.
- Subjects :
- Genetic Markers
Male
Carcinoma, Transitional Cell
Base Sequence
Ureteral Neoplasms
Age Factors
Genetic Counseling
Urography
Middle Aged
Kidney
Prognosis
Colorectal Neoplasms, Hereditary Nonpolyposis
Polymerase Chain Reaction
Kidney Neoplasms
Neoplasms, Multiple Primary
Risk Factors
Lymphatic Metastasis
Humans
Female
Ureter
Germ-Line Mutation
Aged
Microsatellite Repeats
Neoplasm Staging
Subjects
Details
- Language :
- French
- ISSN :
- 07554982
- Volume :
- 34
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Presse medicale (Paris, France : 1983)
- Accession number :
- edsair.pmid..........8ab0303590cf686a9e4c6f499b0e299c