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Association between Serum Mg
- Source :
- Nutrients
- Publication Year :
- 2020
-
Abstract
- Magnesium (Mg2+) levels are associated with insulin resistance, hypertension, atherosclerosis, and type 2 diabetes (T2DM). We evaluated the clinical utility of physiological Mg2+ in assessing subclinical cardiovascular organ damage including increased carotid artery intima- media thickness (c-IMT) and left ventricular mass index (LVMI) in a cohort of well-characterized adult non-diabetic individuals. Age- and gender-adjusted correlations between Mg2+ and metabolic parameters showed that Mg2+ circulating levels were correlated negatively with body mass index (BMI), fasting glucose, and 2h-oral glucose tolerance test (OGTT) glucose. Similarly, Mg2+ levels were significantly and negatively related to c-IMT and LVMI. A multivariate regression analysis revealed that age (β = 0.440; p < 0.0001), BMI (β = 0.225; p < 0.0001), and Mg2+ concentration (β = −0.122; p < 0.01) were independently associated with c-IMT. Age (β = 0.244; p = 0.012), Mg2+ (β = −0.177; p = 0.019), and diastolic blood pressure (β = 0.184; p = 0.038) were significantly associated with LVMI in women, while age (β = 0.211; p = 0.019), Mg2+ (β = −0.171; p = 0.038) and the homeostasis model assessment index of insulin resistance (HOMA-IR) (β = −0.211; p = 0.041) were the sole variables associated with LVMI in men. In conclusion, our data support the hypothesis that the assessment of Mg2+ as part of the initial work-up might help unravel the presence of subclinical organ damage in subjects at increased risk of cardiovascular complications.
- Subjects :
- Adult
Male
Risk
subclinical atherosclerosis
Heart Ventricles
Middle Aged
magnesium
Atherosclerosis
Carotid Intima-Media Thickness
Article
carotid-intima media thickness
Cohort Studies
Diabetes Mellitus, Type 2
Cardiovascular Diseases
cardiovascular disease
Hypertension
Humans
Female
Insulin Resistance
left ventricular mass index
Biomarkers
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 12
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.pmid..........89f2f8d8104dcda41754991843d28d5f