[The role of local factors regulating vascular blood flow in the development of hypoxia of the gastric mucosa in peptic ulcer]

In 50 patients with gastric ulcer indices of oxygen tension (pO2) levels were investigated in correlation with the concentration of prostaglandins (E and F2 alpha), prostacyclin, thromboxane as well as with values of transmucous difference of potentials in different parts of the gastric mucosa, they were compared with 30 healthy controls. It has been assumed that the detected increase of reverse diffusion of hydrogen ions (the appearance of positive values of the transmembranous potential) and disorder of the ratio of prostanoids in favor of vasoconstrictors lead to a decrease in the blood flow and pO2 in the periulcerative zone of the patients with gastric ulcer. Hypoxia of the gastric mucosa is regarded as an important pathogenetic factor of ulcerogenesis.