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Application of newly synthesized 1-34 human parathyroid hormone for diagnostic tests
- Source :
- Pharmatherapeutica. 3(2)
- Publication Year :
- 1982
-
Abstract
- 1-34 human parathyroid hormone (1-34 hPTH) was synthesized by a liquid-phase method and prepared for clinical use (specific activity, 3281 U/mg). With this preparation, the toxicity was studied in 22 normal volunteers and the metabolic effects in 15 individuals. Intradermal administration of 4 ng of 1-34 hPTH caused neither abnormal local skin reactions nor toxicity in terms of subjective and objective parameters. When administered intravenously at doses of from 2 to 20 microgram as a bolus, the preparation caused no acute or subacute toxicity judging from the results of various clinical and laboratory studies, except for transient mild hypotension and headache in a minority of subjects. For diagnostic use, 20 microgram of 1-34 hPTH administered intravenously was found to produce effects almost equivalent to those of 200 USPU U of Parathormone (PTE, Eli Lilly). Thus, the criteria for differentiation of hypoparathyroidism from pseudo-hypoparathyroidism devised with 2000 USP U of PTE as a test substance was found to be applicable when 20 microgram of 1-34 hPTH was utilized.
Details
- ISSN :
- 0308051X
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Pharmatherapeutica
- Accession number :
- edsair.pmid..........828c36b548ae7b4182e8d486e4754a2d