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[Impulse cytophotometric studies of bone marrow and blood cells in children with acute lymphoblastic leukemia (ALL). 1. Bone marrow cells]
- Source :
- Folia haematologica (Leipzig, Germany : 1928). 114(4)
- Publication Year :
- 1987
-
Abstract
- 1. Compared with the peripheral blood lymphocytes of healthy children the cell fractions in the S- and G2 + M-phase are significantly higher in the bone-marrow of those children affected with ALL. This increase was proved in the SR- and MR-group irrespective of the cytomorphological subtype and cytochemical reaction. In patients with relapses the percentage of S-phase cells is below 6%. 2. In about 30% of our patients (mainly in the SR-group with L1-morphology) an initial DNA-aneuploidy was identified. As the risk of relapse is higher in children without DNA-aneuploidy, this symptom has a pretherapeutical-prognostic significance. 3. In the phase of hematological full remission, DNA-frequency distribution correlates with the proliferative activity of normal hematopoiesis. It provides no additional information about the pretherapeutical risk.
Details
- Language :
- German
- ISSN :
- 03234347
- Volume :
- 114
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Folia haematologica (Leipzig, Germany : 1928)
- Accession number :
- edsair.pmid..........814a51a6953397a2e8b6e6c35b35ec61