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Expression of nucleophosmin in glandular epithelium of non-pregnant human endometrium during the menstrual cycle

Authors :
Ye, Kuang
Peng, Xu
Hai-Xia, Wen
Xian-Chao, Kong
Li-Li, Guan
Pei-Ling, Li
Source :
Chinese medical journal. 124(16)
Publication Year :
2011

Abstract

Nucleophosmin plays a critical role in embryonic development. This study aimed to examine the expression pattern of nucleophosmin in glandular epithelium of human endometrium during the menstrual cycle.Endometrial tissues used for this study were obtained from 46 non-pregnant patients who underwent hysterectomy which had been performed to treat benign diseases. Nucleophosmin expression was assessed by in situ hybridization and immunohistochemistry.At the early-, mid- and late-proliferative phase, nucleophosmin mRNA was highly expressed in glandular epithelium of human endometrium. At the secretory phase, the expression of nucleophosmin mRNA was reduced in glandular epithelium in early-secretory phase, and the expression in mid- and late-secretory phases was not detected. Similarly, nucleophosmin protein was strongly expressed in endometrial glands throughout the proliferative phase, but was gradually reduced during secretory phase.Nucleophosmin mRNA and protein are expressed in glandular epithelium of human endometrium throughout the menstrual cycle.

Details

ISSN :
25425641
Volume :
124
Issue :
16
Database :
OpenAIRE
Journal :
Chinese medical journal
Accession number :
edsair.pmid..........7ff16f17fe05b0c90c7f21ca0bc01f3b