CpG Site-Specific Methylation-Modulated Divergent Expression of

Hepatocellular carcinoma (HCC) is one of the most lethal human tumors with extensive intratumor heterogeneity (ITH). Serine protease 3 (PRSS3) is an indispensable member of the trypsin family and has been implicated in the pathogenesis of several malignancies, including HCC. However, the paradoxical effects ofThe expression and DNA methylation ofThese results provide the first evidence for the transcriptional and functional characterization of