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Anti-Inflammatory and Skin-Moisturizing Effects of a Flavonoid Glycoside Extracted from the Aquatic Plant
- Source :
- Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
- Publication Year :
- 2018
-
Abstract
- Nymphoides indica, an aquatic plant, is used as folk medicine in some countries. Our previous study demonstrated that the methanol extract of N. indica inhibited the activity of tyrosinases, tyrosine related protein (TRP)1 and TRP2, and microphthalmia-associated transcription factor, as well as the activity of protein kinase A, by effectively inhibiting cyclic adenosine monophosphate. Although the biological activities of N. indica extract have been reported, there are no reports on the skin bioactivity of the main compound(s) on human keratinocytes. This study investigated the anti-inflammatory and moisturizing effects of quercetin 3,7-dimethyl ether 4′-glucoside (QDG) isolated from N. indica. In brief, ultraviolet B irradiated keratinocytes were pretreated with different concentrations of QDG, and the effects of QDG on various inflammatory markers were determined. QDG significantly inhibited inflammation-related cytokines and chemokines and enhanced the activation of skin barrier factors. Additionally, QDG also attenuated phosphorylation inhibition of the upstream cytokines and nuclear factor-κB expression. These results suggest that QDG isolated from N. indica may serve as a potential source of bioactive substances for chronic inflammatory skin diseases.
- Subjects :
- Keratinocytes
Aquatic Organisms
quercetin 3,7-dimethyl ether 4′-glucoside
Plant Extracts
Anti-Inflammatory Agents
food and beverages
Asteraceae
Article
Cell Line
Nymphoides indica
skin moisturizing
Gene Expression Regulation
Cell Movement
Cytokines
Humans
Quercetin
Glycosides
Phosphorylation
Cell Proliferation
anti-inflammatory
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 23
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.pmid..........7f9ac708ce91cc3c2d8e114d99811381