Serum TNF in patients with severe malaria treated by exchange transfusion

Authors :: L, Loutan
C, Plancherel
M, Soulier-Lauper
M, Pascual
L, Subilia
J C, Chevrolet
P F, Unger
G E, Grau
Source :: Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ). 43(4)
Publication Year :: 1992
Abstract: The authors report on three cases of severe P. falciparum malaria successfully treated by iv quinine and exchange transfusion. Serum concentrations of Tumor Necrosis Factor (TNF) were determined before and during treatment. After an initial decrease, serum levels of TNF remained markedly elevated during the first 48 hours despite exchange transfusion. Though exchange transfusion accelerates the elimination of parasites from the blood, it seems to have no immediate effects on reducing serum levels of cytokines such as TNF.

Subjects :: Adult
Male
Quinine
Chemotherapy, Adjuvant
Tumor Necrosis Factor-alpha
Exchange Transfusion, Whole Blood
Humans
Malaria, Falciparum
Middle Aged
Infusions, Intravenous

ISSN :: 01772392
Volume :: 43
Issue :: 4
Database :: OpenAIRE
Journal :: Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)
Accession number :: edsair.pmid..........7cc87574d38fd7c891c403a7db294a24

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