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- Source :
- Viral immunology. 32(9)
- Publication Year :
- 2019
-
Abstract
- Porcine reproductive and respiratory syndrome virus (PRRSV) still poses a threat to the swine industry worldwide. Currently, commercial vaccines against PRRSV, which consist of modified live or inactivated virus, reduce symptoms and viremia in immunized pigs, but efficacy against heterologous strains is variable. This has led to the development of subunit vaccines that contain viral antigens that show the highest variability. In this work, a chimeric protein comprising short amino acid sequences from glycoprotein 3 (GP3), glycoprotein 4 (GP4), glycoprotein 5 (GP5), and M (matrix protein) proteins of PRRSV was designed and expressed in
- Subjects :
- Vaccines, Synthetic
Swine
Recombinant Fusion Proteins
Vaccination
Porcine Reproductive and Respiratory Syndrome
Viral Vaccines
Antibodies, Viral
Epitopes
Mice
Viral Proteins
Immunogenicity, Vaccine
RAW 264.7 Cells
Immunoglobulin G
Escherichia coli
Animals
Female
Porcine respiratory and reproductive syndrome virus
Antigens, Viral
Glycoproteins
Subjects
Details
- ISSN :
- 15578976
- Volume :
- 32
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Viral immunology
- Accession number :
- edsair.pmid..........7c0beb1ba530351f9671b415fea5133e