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Toxicological and Anti-Rheumatic Potential of
- Source :
- International Journal of Nanomedicine
- Publication Year :
- 2019
-
Abstract
- Purpose The existing treatment modalities for rheumatoid arthritis are less effective and safe, therefore it is essential to develop new treatments that particularly target the inflamed joints with decreased off-target side-effects. The current study proposes a nanoparticle-based therapeutic approach to target the anti-oxidant defense system of arthritic Balb/c mice. Methods Biogenic selenium nanoparticles (SeNPs) were synthesized by using Trachyspermum ammi seed extract and were evaluated for their toxicological, as well as their therapeutic potential in collagen-induced arthritic mice. Results The tested doses of SeNPs had no significant toxic effects on liver, kidney, spleen, and serum biochemical parameters in comparison to healthy mice. The SeNPs treatment reduced the disease severity, as demonstrated by decreased paw edema along with reduced lymphocytic cellular infiltration in the histopathological findings. SeNPs also revealed dose-independent improvement in the redox state of inflamed synovium by significantly improving the activity of antioxidant enzymes in comparison to the arthritic controls. Conclusion It is therefore concluded that nano-selenium in combination with TAE extract showed enhanced therapeutic efficacy as compared to their individual effects.
- Subjects :
- rheumatoid arthritis
Mice, Inbred BALB C
Spectrophotometry, Infrared
Plant Extracts
Body Weight
Catalase
collagen-induced arthritis
Antioxidants
Arthritis, Rheumatoid
Selenium
Liver
Antirheumatic Agents
selenium nanoparticles
Animals
Edema
Nanoparticles
Cattle
Female
Spectrophotometry, Ultraviolet
Trachyspermum ammi
Oxidation-Reduction
Spleen
Apiaceae
Original Research
Subjects
Details
- ISSN :
- 11782013
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- International journal of nanomedicine
- Accession number :
- edsair.pmid..........7c053ebaf8354af52abb535f3b3b1fdd