The Accumulating Data to Optimally Predict Obesity Treatment (ADOPT) Core Measures Project: Rationale and Approach

Background Individual variability in response to multiple modalities of obesity treatment is well documented yet our understanding of why some individuals respond while others do not is limited. The etiology of this variability is multi-factorial, but at present we lack a comprehensive evidence base to identify which factors or combination of factors influence treatment response. Objectives This paper provides an overview and rationale of the Accumulating Data to Optimally Predict obesity Treatment (ADOPT) Core Measures Project, which aims to advance understanding of individual variability in response to adult obesity treatment. We provide an integrated model for how factors in the behavioral, biological, environmental, and psychosocial domains may influence obesity treatment responses and identify a core set of measures to be used consistently across adult weight loss trials. This paper provides the foundation for four companion papers that describe the core measures in detail. Significance The accumulation of data on factors across the four ADOPT domains can inform the design and delivery of effective, tailored obesity treatments. ADOPT provides a framework for how obesity researchers collectively can generate this evidence base and is a first step in an ongoing process that can be refined as the science advances.