The in vitro activity of selected mouthrinses on Candida strains isolated from the oral cavity

The purpose of this in vitro study was to determine the effects of 13 mouth rinses on one hundred Candida strains isolated from the oral cavity of patients. Five of the rinses had no antifungal activity. Chlorhexidine, Colgate and Dentosept acted on all isolated strains; Corsodyl did not act on C. glabrata (2 strains), Octenidol on C. glabrata and C. guilliermondii (1 each), Sylveco on C. tropicalis (2), Oral B on C. parapsilosis, Curasept did not affect 17 strains, including on C. albicans (5), C. guilliermondii (4), C. dubliniensis (3), C. humicola and C. parapsilosis (2 each) and C. glabrata (1). The lowest MIC (the strongest potential activity), was observed for chlorhexidine, followed by Sylveco, Corsodryl and Colgate; in contrast, the highest MIC (the lowest activity) was calculated for Octenidol and Curasept. Eight of the mouthrinses inhibited the in vitro growth of potentially pathogenic fungal strains isolated from the oral cavity at varying dilutions of up to 1:16, depending on the rinse. Chlorhexidine demonstrated strong antifungal efficiency. The antifungal effect of a mouthrinse depends on its composition and the species of fungus. Mouthrinse use is an important complement to procedures ensuring proper oral hygiene and preventing certain oral diseases.