Defucosylated Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 134-mG

Authors :: Nami, Tateyama
Ren, Nanamiya
Tomokazu, Ohishi
Junko, Takei
Takuro, Nakamura
Miyuki, Yanaka
Hideki, Hosono
Masaki, Saito
Teizo, Asano
Tomohiro, Tanaka
Masato, Sano
Manabu, Kawada
Mika K, Kaneko
Yukinari, Kato
Source :: Monoclonal antibodies in immunodiagnosis and immunotherapy. 40(4)
Publication Year :: 2021
Abstract: The epidermal growth factor receptor (EGFR) is a type I transmembrane protein, which is a member of the human epidermal growth factor receptor (HER) family of receptor tyrosine kinases. EGFR is a crucial mediator of cell growth and differentiation and forms homodimers or heterodimers with other HER family members to activate downstream signaling cascades. We previously established an anti-human EGFR (hEGFR) monoclonal antibody (mAb), clone EMab-134 (mouse IgG