Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT

Authors :: Anna, Więckowska
Marcin, Kołaczkowski
Adam, Bucki
Justyna, Godyń
Monika, Marcinkowska
Krzysztof, Więckowski
Paula, Zaręba
Agata, Siwek
Grzegorz, Kazek
Monika, Głuch-Lutwin
Paweł, Mierzejewski
Przemysław, Bienkowski
Halina, Sienkiewicz-Jarosz
Damijan, Knez
Tomasz, Wichur
Stanislav, Gobec
Barbara, Malawska
Source :: European journal of medicinal chemistry. 124
Publication Year :: 2016
Abstract: As currently postulated, a complex treatment may be key to an effective therapy for Alzheimer's disease (AD). Recent clinical trials in patients with moderate AD have shown a superior effect of the combination therapy of donepezil (a selective acetylcholinesterase inhibitor) with idalopirdine (a 5-HT

Subjects :: Male
Models, Molecular
Protein Conformation
Chemistry Techniques, Synthetic
Ligands
Rats
Kinetics
Alzheimer Disease
Blood-Brain Barrier
Butyrylcholinesterase
Catalytic Domain
Drug Design
Receptors, Serotonin
Acetylcholinesterase
Animals
Humans
Cholinesterase Inhibitors
Molecular Targeted Therapy
Rats, Wistar

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