Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from

Authors :: Daria, Monaldi
Dante, Rotili
Julien, Lancelot
Martin, Marek
Nathalie, Wössner
Alessia, Lucidi
Daniela, Tomaselli
Elizabeth, Ramos-Morales
Christophe, Romier
Raymond J, Pierce
Antonello, Mai
Manfred, Jung
Source :: Journal of medicinal chemistry. 62(19)
Publication Year :: 2019
Abstract: The only drug currently available for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary and urgent. To this end, the targeting of

Subjects :: Niacinamide
Oxadiazoles
Lysine
Helminth Proteins
Schistosoma mansoni
Substrate Specificity
Kinetics
Structure-Activity Relationship
Pyrimidines
Sirtuin 2
Larva
Animals
Humans
Schistosomiasis
Peptides

Tools