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High dose of amiodarone in a short-term period reduces the incidence of postoperative atrial fibrillation and atrial flutter
- Source :
- Arquivos brasileiros de cardiologia. 87(3)
- Publication Year :
- 2005
-
Abstract
- To investigate whether oral amiodarone administered before surgery for a short period in high dose would reduce the incidence of postoperative atrial fibrillation or atrial flutter and reduces the length of hospital stay.In the double-blind, randomized study, 93 patients were given either oral amiodarone (46 patients) or placebo (47 patients). Therapy consisted of 600 mg of amiodarone three times a day, started at minimum 30 hours and at maximum 56 hours before surgery.Postoperative atrial fibrillation or atrial flutter occurred in 8 of 46 patients in the amiodarone group (17.4%) and 19 of the 47 patients in the placebo group (40.4%) (p=0.027). The mean dose of amiodarone was 2.8 g. Patients in the amiodarone group were hospitalized for 8.9+/-3.1 days and patients in the placebo group were hospitalized for 11.4+/-8.7 days (p=0.07). The hospital length were significantly prolonged in patients who developed atrial arrhythmias after surgery, despite the treatment received.(p0.001).This new alternative way of using amiodarone in high dose and in a short-term period before surgery reduce the incidence of postoperative atrial fibrillation or atrial flutter in coronary artery bypass graft surgery.
Details
- ISSN :
- 16784170
- Volume :
- 87
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Arquivos brasileiros de cardiologia
- Accession number :
- edsair.pmid..........6d50251bde2d0c80cc4c3e757b23b4ac