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An increased number of gamma/delta T-cells and gastric epithelial cell expression of the groEL stress-protein homologue in Helicobacter pylori-associated chronic gastritis of the antrum
- Source :
- The American journal of gastroenterology. 86(8)
- Publication Year :
- 1991
-
Abstract
- Numerous studies have shown that the presence of Helicobacter pylori in the stomach is linked to the development of chronic gastritis most commonly seen in the antrum. However, the pathogenic mechanisms are unclear. In 23 of 31 patients, examined due to symptoms from the upper gastrointestinal tract, H. pylori-associated chronic gastritis of the antrum was diagnosed histologically and by growth of H. pylori. Immunoperoxidase staining on gastric biopsy specimens from these patients showed an increased number of gamma/delta T-cells within the epithelium. Furthermore, the Mab ML30 (raised against the 65 kDa heat shock protein of mycobacteria) demonstrated positive staining in the gastric epithelial cells in all H. pylori-positive but not in H. pylori-negative biopsy specimens. H. pylori also reacted with ML30, as detected by immunoperoxidase staining as well as by immunoblotting. Intraepithelial gamma/delta T cells may play a role in host defense against invading H. pylori, and the bacteria may trigger an autoimmune response to stress proteins expressed by the gastric epithelial cells.
- Subjects :
- Adult
Aged, 80 and over
Male
Helicobacter pylori
Biopsy
T-Lymphocytes
Blotting, Western
Receptors, Antigen, T-Cell
Gene Expression
Chaperonin 60
Middle Aged
Helicobacter Infections
Immunoenzyme Techniques
Leukocyte Count
Bacterial Proteins
Gastric Mucosa
Gastritis
Escherichia coli
Pyloric Antrum
Humans
Female
Heat-Shock Proteins
Aged
Subjects
Details
- ISSN :
- 00029270
- Volume :
- 86
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The American journal of gastroenterology
- Accession number :
- edsair.pmid..........6c2fbef0fab093cb90e222d445708999