[Structure-activity relationships of phenylethanoid glycosides in plants of Cistanche salsa on antioxidative activity]

To study the structure-activity relationships of phenylethanoid glycosides in plants of Cistanche salsa on antioxidative activity.By the assay systems of DPPH*, the antioxidant activity of six phenylethanoid glycosides from plants of Cistanche salsa was determined to investigate the relationship between the antioxidant activities and phenylethanoid glycosides's structural characteristics.The antioxidative activity of phenylethanoid glycosides was variant with dose-dependent effect. The sequence of the strength of the antioxidative activity of the six components was shown to be 2'-AcetylacteosideActeosideor = Tubuloside Bor = IsoacteosideEchinacosideCistanoside A.The antioxidative activity of phenylethanoid glycosides is related to the number of phenolic hydroxyl, steric hindrance, 2-acetyl on the middle glucopyranose, and the location of phenolic hydroxyl. Additionally, it may be related to the alpha, beta-unsaturated ketone of phenl-2-propenoyl.