[Effect of micropolarization of focal and extrafocal brain structures on experimental epilepsy]

The influence of micropolarization (MCP, 0.05-0.75 muA) was studied in chronic experiments on rabbits with epileptogenic foci provoked by penicillin (doses of 500 and 1000 U) injection into the motor cortex. A single MCP of extrafocal structure (the corpus calossum, nucleus caudatus) and the site of the focus inhibited the development of seizure reactions. Numerous MCP of the focus facilitated the seizure reactions. These effects may be explained not only by the specific role of the structures studied in the processes of the formation and propagation of the excitation, their initial functional state, but also by the dependence of the activity of these structures on the MCP regimen.