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Medicinal flowers. XXXV. Nor-oleanane-type and acylated oleanane-type triterpene saponins from the flower buds of Chinese Camellia japonica and their inhibitory effects on melanogenesis
- Source :
- Chemicalpharmaceutical bulletin. 60(9)
- Publication Year :
- 2012
-
Abstract
- The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia japonica, cultivated in Yunnan Province, China, showed inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells. From the 1-butanol-soluble fraction, a new 28-nor-oleanane-type and three new oleanane-type triterpene saponins, sanchakasaponins A-D, were isolated together with four known triterpene saponins. Their chemical structures were elucidated on the basis of chemical and physicochemical evidence. The inhibitory effects on melanogenesis in theophylline-stimulated B16 melanoma 4A5 cells and structure-activity relationships of the saponins were investigated.
Details
- ISSN :
- 13475223
- Volume :
- 60
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Chemicalpharmaceutical bulletin
- Accession number :
- edsair.pmid..........6bd8e4006eca3682da808bb6d8cc56cf