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The mouse Anxa6/miR-9-5p/Anxa2 axis modulates TGF-β1-induced mouse hepatic stellate cell (mHSC) activation and CCl
- Source :
- Toxicology letters. 362
- Publication Year :
- 2022
-
Abstract
- Chronic liver disease such as hepatic fibrosis is a major cause of morbidity and mortality and has been related to high individual risk of hepatocellular carcinoma (HCC). Hepatic stellate cells (HSCs) activation is a central event of hepatic fibrosis progression. In this study, the up-regulation of lncRNA ANXA2P2 (mouse Anxa6) was found in liver fibrosis. Within CCl
- Subjects :
- Liver Cirrhosis, Experimental
Transforming Growth Factor beta1
Mice
MicroRNAs
Phosphatidylinositol 3-Kinases
Liver Neoplasms, Experimental
Hepatic Stellate Cells
Animals
RNA, Long Noncoding
Annexin A6
Carbon Tetrachloride
Proto-Oncogene Proteins c-akt
Annexin A2
Cell Proliferation
Signal Transduction
Subjects
Details
- ISSN :
- 18793169
- Volume :
- 362
- Database :
- OpenAIRE
- Journal :
- Toxicology letters
- Accession number :
- edsair.pmid..........68a9889193db29dd864c5f04c90e5942