Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA

Regeneration of the epithelium by stem cells in the intestine is supported by intrinsic and extrinsic factors. Lysophosphatidic acid (LPA), a bioactive lipid mediator, regulates many cellular functions, including cell proliferation, survival, and cytokine secretion. Here, we identify LPAWe have used genetic mouse models of conditional deletion of Lpar5, Lpar5Conditional loss of Lpar5 induced ablation of the intestinal mucosa, which increased morbidity of Lpar5LPA