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Improvement of Duchenne muscular dystrophy phenotype following obestatin treatment
- Source :
- Journal of Cachexia, Sarcopenia and Muscle
- Publication Year :
- 2017
-
Abstract
- Background This study was performed to test the therapeutic potential of obestatin, an autocrine anabolic factor regulating skeletal muscle repair, to ameliorate the Duchenne muscular dystrophy (DMD) phenotype. Methods and results Using a multidisciplinary approach, we characterized the ageing‐related preproghrelin/GPR39 expression patterns in tibialis anterior (TA) muscles of 4‐, 8‐, and 18‐week‐old mdx mice (n = 3/group) and established the effects of obestatin administration at this level in 8‐week‐old mdx mice (n = 5/group). The findings were extended to in vitro effects on human immortalized DMD myotubes. An analysis of TAs revealed an age‐related loss of preproghrelin expression, as precursor of obestatin, in mdx mice. Administration of obestatin resulted in a significant increase in tetanic specific force (33.0% ± 1.5%, P
- Subjects :
- Male
Duchenne muscular dystrophy
Muscle Fibers, Skeletal
Skeletal muscle
Receptors, G-Protein-Coupled
Mice
Sarcolemma
Obestatin signalling
Animals
Humans
Muscle Strength
Muscle, Skeletal
Original Articles
Ghrelin
Rats
Muscular Dystrophy, Duchenne
Disease Models, Animal
Phenotype
Pharmacological modifier
Protein Biosynthesis
Skeletal muscle cell atrophy
Proteolysis
Mice, Inbred mdx
Original Article
Oxidation-Reduction
Biomarkers
Subjects
Details
- ISSN :
- 21906009
- Volume :
- 9
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of cachexia, sarcopenia and muscle
- Accession number :
- edsair.pmid..........656849c341aea1be43d95eccab302e27