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Up-regulated miR-155-5p promotes cell proliferation, invasion and metastasis in colorectal carcinoma
- Publication Year :
- 2015
- Publisher :
- e-Century Publishing Corporation, 2015.
-
Abstract
- Background and objective: Emerging evidences indicate that miR-155-5p is associated with some cancer tumorigenesis, but their specific effects on proliferation, invasion and metastasis of colorectal carcinoma (CRC) are still poorly understood. The aim of the study is to investigate miR-155-5p effect on proliferation and invasion metastasis of CRC. Methods: Retrospectively analyzed clinicopathological parameters and fresh tissue samples of 372 colon cancer patients receiving radical surgery. HT-29 cells were transfected with mimics and inhibitors of miR-155-5p, respectively. Real-time reverse transcription-PCR was performed to measure miR-155-5p relative levels of tissues and cells. Results: miR-155-5p expression in cancer group was higher than that in normal group, with statistical differences (P
- Subjects :
- Male
Reverse Transcriptase Polymerase Chain Reaction
Carcinoma
Middle Aged
Real-Time Polymerase Chain Reaction
Transfection
Up-Regulation
Gene Expression Regulation, Neoplastic
MicroRNAs
Cell Movement
Humans
Original Article
Female
Neoplasm Invasiveness
Neoplasm Grading
Colorectal Neoplasms
HT29 Cells
Aged
Cell Proliferation
Neoplasm Staging
Retrospective Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid..........63bdce5176cde719613af37d3684d7e0