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The Importance of Probe Location for the Interpretation of Cerebral Microdialysis Data in Subarachnoid Hemorrhage Patients
- Source :
- Neurocritical Care
- Publication Year :
- 2019
-
Abstract
- Background There is no uniform definition for cerebral microdialysis (CMD) probe location with respect to focal brain lesions, and the impact of CMD-probe location on measured molecule concentrations is unclear. Methods We retrospectively analyzed data of 51 consecutive subarachnoid hemorrhage patients with CMD-monitoring between 2010 and 2016 included in a prospective observational cohort study. Microdialysis probe location was assessed on all brain computed tomography (CT) scans performed during CMD-monitoring and defined as perilesional in the presence of a focal hypodense or hyperdense lesion within a 1-cm radius of the gold tip of the CMD-probe, or otherwise as normal-appearing brain tissue. Results Probe location was detected in normal-appearing brain tissue on 53/143 (37%) and in perilesional location on 90/143 (63%) CT scans. In the perilesional area, CMD-glucose levels were lower (p = 0.003), whereas CMD-lactate (p = 0.002), CMD-lactate-to-pyruvate-ratio (LPR; p
- Subjects :
- Glycerol
Male
Cerebral microdialysis
Microdialysis
Glutamic Acid
Brain Edema
Cerebral metabolism
Aneurysm, Ruptured
Brain Ischemia
Cohort Studies
Stress, Physiological
Pyruvic Acid
Humans
Subarachnoid hemorrhage
Lactic Acid
Prospective Studies
Secondary brain injury
Computed tomography
Aged
Monitoring, Physiologic
Retrospective Studies
Brain
Intracranial Aneurysm
Middle Aged
Mitochondria
Glucose
Female
Original Work
Hydrocephalus
Subjects
Details
- ISSN :
- 15560961
- Volume :
- 32
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Neurocritical care
- Accession number :
- edsair.pmid..........63175e1b0fd676f3dd5edcfbc878bae2