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Generation of human endothelium in pig embryos deficient in ETV2

Authors :
Satyabrata, Das
Naoko, Koyano-Nakagawa
Ohad, Gafni
Geunho, Maeng
Bhairab N, Singh
Tara, Rasmussen
Xiaoyan, Pan
Kyung-Dal, Choi
Daniel, Mickelson
Wuming, Gong
Pruthvi, Pota
Cyprian V, Weaver
Stefan, Kren
Jacob H, Hanna
Demetris, Yannopoulos
Mary G, Garry
Daniel J, Garry
Source :
Nature biotechnology. 38(3)
Publication Year :
2018

Abstract

The scarcity of donor organs may be addressed in the future by using pigs to grow humanized organs with lower potential for immunological rejection after transplantation in humans. Previous studies have demonstrated that interspecies complementation of rodent blastocysts lacking a developmental regulatory gene can generate xenogeneic pancreas and kidney

Details

ISSN :
15461696
Volume :
38
Issue :
3
Database :
OpenAIRE
Journal :
Nature biotechnology
Accession number :
edsair.pmid..........613f6decc0e9ea69d0a2acfa9be52660