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Elevated serum soluble Fas ligand in natural killer cell proliferative disorders
- Source :
- British journal of haematology. 103(4)
- Publication Year :
- 1999
-
Abstract
- We evaluated the serum level of soluble Fas ligand (sFasL) in patients with natural killer lymphocyte proliferative disorders (NK- LPD). The serum sFasL level was elevated in neoplastic groups of aggressive NK leukaemia, indolent NK leukaemia and NK lymphoma, all of which contained clonal EBV-DNA. In NK leukaemia the serum sFasL level was significantly higher than that found in others. However, it was not elevated in the patients with reactive NK-LPD and in one patient with NK leukaemia in remission. These findings indicate that the serum sFasL level is a useful indicator in evaluating disease activity.
Details
- ISSN :
- 00071048
- Volume :
- 103
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- British journal of haematology
- Accession number :
- edsair.pmid..........5ee20d86ac678abaa60ad85220478260