[Clinical Characteristics and Prognosis Analysis of Pediatric Severe Aplastic Anemia]

To analyze the clinical characteristics and factors affecting prognosis in children with severe aplastic anemia (SAA).Two hundred and five children with SAA treated in our department from January 2008 to April 2018 were selected, and the clinical characteristics and factors affecting prognosis were retrospectively analyzed.Among 205 SAA children, the effective rate (CR+PR) at 3, 6 and 12 months after immunosuppressive therapy (IST) treatment was 50.9%, 59.0% and 73.9%, respectively, and 5-year overall survival rate was 93.1%±2.0%. Univariate analysis showed that 5-year overall survival rate of SAA children of spontaneous delivery was higher than that of cesarean section (P=0.039), while multivariate analysis showed that birth way had no significant influence on 5-year overall survival rate (P0.05). The response rate at 3 months after IST of children with a recent history of decoration before SAA onset was higher than those without history of decoration (P0.05).Most of the SAA children can achieve high response rate and overall survival rate. Patients with recent history of home/school decoration may be the factor affecting hematological response after 3 months of IST, but have no influence on long-term overall survival.重型再生障碍性贫血患儿的临床特征及预后分析.分析重型再生障碍性贫血(SAA)患儿的基本临床特征及预后影响因素。.选择2008年1至2018年4月收治的SAA患儿205例，对其基本临床特征及预后影响因素进行回顾性分析。.205例SAA患儿中，免疫抑制治疗（IST）后3、6和12个月的有效率（CR+PR）分别为50.9%、59.0%和73.9%，患儿5年总生存（OS）率为93.1%±2.0%。单因素生存分析显示，顺产出生的SAA患儿较剖宫产出生者5年OS率高（P=0.039），多因素Cox回归模型分析显示，出生方式对SAA患儿5年OS率无显著影响（P0.05）。发病近期有装修材料接触史的SAA患儿IST后3个月反应率高于无装修材料接触史的SAA患儿（P0.05）。.SAA患儿经IST治疗后可获得较高的反应率和OS率，发病近期有家庭/学校装修材料接触史可能为SAA患儿IST后3个月反应率的影响因素，但对患儿长期生存未见显著影响。.