Oncogenic

Authors :: Adam T, Boutin
Wen-Ting, Liao
Melody, Wang
Soyoon Sarah, Hwang
Tatiana V, Karpinets
Hannah, Cheung
Gerald C, Chu
Shan, Jiang
Jian, Hu
Kyle, Chang
Eduardo, Vilar
Xingzhi, Song
Jianhua, Zhang
Scott, Kopetz
Andrew, Futreal
Y Alan, Wang
Lawrence N, Kwong
Ronald A, DePinho
Source :: Genesdevelopment. 31(4)
Publication Year :: 2016
Abstract: Here, Boutin et al. investigated the role of oncogenic KRAS in colorectal cancer (CRC). They generated a mouse model of metastatic CRC that harbors an inducible oncogenic Kras allele (Krasmut) and conditional null alleles of Apc and Trp53 (iKAP), which provides genetic evidence that Krasmut drives CRC invasion and maintenance of metastases.