[Role of autophagy in the pathogenesis of periodontitis]

Periodontitis is a chronic inflammatory disease of periodontal tissues initiated by oral biofilm. Cellular autophagy is an effective weapon against bacterial infection. Recent studies have shown that autophagy not only promotes the removal of bacteria and toxins from infected cells, but also helps to suppress the inflammatory response to maintain the homeostasis of intracellular environment, which is closely related to the development of periodontitis. Here, we reviewed the relationship between autophagy and periodontitis from three aspects: the interactions between autophagy and periodontal pathogen infection, the regulation of autophagy and immune inflammatory responses, and the relationship between autophagy and alveolar bone metabolism. We aim to provide ideas for further study on the mechanisms of autophagy and periodontitis, and ultimately contribute to a better prevention and treatment of periodontitis.牙周炎是由牙菌斑生物膜引起的牙周组织的慢性炎症性疾病。细胞自噬是宿主对抗细菌感染的有效武器。近年来研究发现，细胞自噬不仅可以促进感染细胞对细菌和毒素的清除，而且有助于抑制炎症反应，以维持细胞内环境稳态，与牙周炎的发生发展关系密切。本文从细胞自噬与牙周病原菌感染的相互作用，细胞自噬与免疫炎症反应的相互调控，以及细胞自噬与牙槽骨代谢的关系3个方面，对细胞自噬与牙周炎发生发展的关系进行综述，为深入地研究细胞自噬与牙周炎相关机制提供参考，为牙周炎防治的研究提供新的思路。.