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Therapeutic potential of chemokine signal inhibition for metastatic breast cancer
- Source :
- Pharmacological Research
- Publication Year :
- 2015
-
Abstract
- Graphical abstract Tumor-infiltrang immune cells such as metastasis-associated macrophages (MAM), regulatory T (Tregreg) cells, and myeloid-derived suppressor cells (MDSC) are reported to promote establishment of the lethal metasta-c foci and restrict efficacy of cytotoxic drugs or tumoricidal immune responses by natural killer (NK) and CD8+ T cells. Recent studies suggest that these pro-tumor immune cells are accumulated a chemokine network established in the tumor microenvironment. Therefore, blockade of these chemokine signals could improve therapeu-c efficacy of chemotherapy and immunotherapy.<br />Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.
- Subjects :
- Macrophage
Macrophages
CXCR, CXC-chemokine receptor
Breast Neoplasms
Invited Perspective
IM, inflammatory monocyte
CSF-1, colony stimulating factor-1
VEGF, vascular endothelial growth factor
Metastasis
CCL, CC-chemokine ligand
CCR, CC-chemokine receptor
Breast cancer
Chemokine
MAM, metastasis-associated macrophages
Tumor Microenvironment
Animals
Humans
Female
Chemokines
CXCL, CXC-chemokine ligand
Subjects
Details
- ISSN :
- 10961186
- Volume :
- 100
- Database :
- OpenAIRE
- Journal :
- Pharmacological research
- Accession number :
- edsair.pmid..........4f86d500246f37ab68b124a812754209