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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients
- Source :
- The Journal of pathology. 247(2)
- Publication Year :
- 2018
-
Abstract
- Glioblastoma (GBM) is the most common and lethal primary malignant brain tumor which lacks efficient treatment and predictive biomarkers. Expression of the epithelial stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been described in GBM, but its functional role has not been conclusively elucidated. Here, we have investigated the role of LGR5 in a large repository of patient-derived GBM stem cell (GSC) cultures. The consequences of LGR5 overexpression or depletion have been analyzed using in vitro and in vivo methods, which showed that, among those with highest LGR5 expression (LGR5
- Subjects :
- Brain Neoplasms
Mice, SCID
Oligodendrocyte Transcription Factor 2
Radiation Tolerance
Receptors, G-Protein-Coupled
Gene Expression Regulation, Neoplastic
Phenotype
Cell Movement
Drug Resistance, Neoplasm
Mice, Inbred NOD
Neoplastic Stem Cells
Tumor Cells, Cultured
Animals
Humans
Neoplasm Invasiveness
Cell Self Renewal
Glioblastoma
Cell Proliferation
Signal Transduction
Subjects
Details
- ISSN :
- 10969896
- Volume :
- 247
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- The Journal of pathology
- Accession number :
- edsair.pmid..........4dbd805e00ef3e9590f81e523293f6a4