[Determination of pesticide residues and microcystin in drinking water using on-line SPE liquid chromatography-mass spectrometry]

To develop a method based on on-line solid phase extraction followed liquid chromatography mass spectrometry for determination of 9 pesticides and microcystin-LR in drinking water.Drinking water samples were concentrated by a HRP-SPE cartridge and separated on a HSS T3 column with a gradient mobile phase of acetonitrile and aqueous 0.1% formic acid, then analyzed by triple quadrupole mass spectrometry (TQ-MS) and time of flight mass spectrometry (TOF-MS), respectively. Mass acquisition was conducted under positive electrospray ionization mode. Quantification was performed by external standard calibration.The quantification limits (LOQs) of 10 target compounds were far below the limits set by the National Standards for Drinking Water Quality. The LOQs of TOF-MS was 0.01-0.40 microg/L and the LOQs of TQ-MS was 0.01-0.19 microg/L. Recoveries of 10 target compounds were 66.5%-130.3% with relative standard deviation between 0.8% and 14.5%.Due to its rapidness, simpleness, and high sensitivity, the method is suitable for the determination of pesticides and microcystin-LR in drinking water.