Prostaglandin E

Authors :: Yi Rang, Na
Daun, Jung
Michelle, Stakenborg
Hyeri, Jang
Gyo Jeong, Gu
Mi Reu, Jeong
Soo Youn, Suh
Hak Jae, Kim
Yoon Hey, Kwon
Tae Sik, Sung
Seung Bum, Ryoo
Kyu Joo, Park
Jong Pil, Im
Ji Yong, Park
Yun Sang, Lee
Heonjong, Han
Boyoun, Park
Sungwook, Lee
Daesik, Kim
Ho Su, Lee
Isabelle, Cleynen
Gianluca, Matteoli
Seung Hyeok, Seok
Source :: Gut. 70(12)
Publication Year :: 2020
Abstract: Dysfunctional resolution of intestinal inflammation and altered mucosal healing are essential features in the pathogenesis of inflammatory bowel disease (IBD). Intestinal macrophages are vital in the process of inflammation resolution, but the mechanisms underlying their mucosal healing capacity remain elusive.We investigated the role of the prostaglandin EHere, we describe a subset of PTGER4-expressing intestinal macrophages with mucosal healing properties both in humans and mice. Csf1r-iCre Ptger4PTGER4