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Drug Target Prediction Using Context-Specific Metabolic Models Reconstructed from rFASTCORMICS

Authors :
Tamara, Bintener
Maria Pires, Pacheco
Ali, Kishk
Jeff, Didier
Thomas, Sauter
Source :
Methods in molecular biology (Clifton, N.J.). 2535
Publication Year :
2022

Abstract

Metabolic modeling is a powerful computational tool to analyze metabolism. It has not only been used to identify metabolic rewiring strategies in cancer but also to predict drug targets and candidate drugs for repurposing. Here, we will elaborate on the reconstruction of context-specific metabolic models of cancer using rFASTCORMICS and the subsequent prediction of drugs for repurposing using our drug prediction workflow.

Details

ISSN :
19406029
Volume :
2535
Database :
OpenAIRE
Journal :
Methods in molecular biology (Clifton, N.J.)
Accession number :
edsair.pmid..........4ba238ab71978e46063d02b52508e141