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Analysis of the tissue marker AgNOR in leukoplaquia and oral squamous cell carcinoma

Analysis of the tissue marker AgNOR in leukoplaquia and oral squamous cell carcinoma

Authors :
Luis Carlos, Cano Montoya
Gloria Jeanethe, Alvarez Gómez
Walter Augusto, Valencia Londoño
Jorge Adolfo, Ramírez España
Carlos Alberto, Prada Navas
Source :
Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal. 7(1)
Publication Year :
2002

Abstract

To determine the prognostic importance of AgNORs and ki-67 in premalignant and malignant lesions in the oral cavity, we carried out a study using retroprospective phases in which 98 histologic sections.26 of mild epithelial dysplasia DEL, 15 of moderate epithelial dysplasia DEM, and 57 of invasive oral squamous cell carcinoma CECO, were stained with silver colloid stain to obtain the average number and type of AgNORs, and immunologic marker Ki-67 to obtain the percentage of cells Ki-67 (+).In both phases the average number of AgNORs and Ki-67 (+) cells was significantly greater in the CECO cases, compared to the dysplasias. The AgNORs type 1 were predominant in the DEL cases and the type 2 in the CECO cases. No statistically significant correlation (Sperman's simple range correlation) was found between the average numbers of AgNORS and the percentage of Ki-67 (+) cells in the three lesions studied. (DEL: p= 0.5113, DEM: p= 0.92 y CECO: p= 0.2584).The results suggest that the AgNOR tissue marker can be used as a routine complementary histopathologic study, since the variations in its number and distribtion indicate existence of cell alterations in a given lesion and the use of this technique is easy and inexpensive.

Details

ISSN :
11372834
Volume :
7
Issue :
1
Database :
OpenAIRE
Journal :
Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal
Accession number :
edsair.pmid..........4b546c11b005ca4534aae72702cf2f03