PET Probes for Preclinical Imaging of GRPR-Positive Prostate Cancer: Comparative Preclinical Study of [

Authors :: Ibolya, Kálmán-Szabó
Judit P, Szabó
Viktória, Arató
Noémi, Dénes
Gábor, Opposits
István, Jószai
István, Kertész
Zita, Képes
Anikó, Fekete
Dezső, Szikra
István, Hajdu
György, Trencsényi
Source :: International journal of molecular sciences. 23(17)
Publication Year :: 2022
Abstract: Gastrin-releasing peptide receptors (GRPR) are overexpressed in prostate cancer (PCa). Since bombesin analogue aminobenzoic-acid (AMBA) binds to GRPR with high affinity, scandium-44 conjugated AMBA is a promising radiotracer in the PET diagnostics of GRPR positive tumors. Herein, the GRPR specificity of the newly synthetized [

Subjects :: Male
Receptors, Bombesin
Heterocyclic Compounds, 1-Ring
Mice
Cell Line, Tumor
Positron-Emission Tomography
Animals
Humans
Prostatic Neoplasms
Bombesin
Gallium Radioisotopes
Acetates

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