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[Junk DNA is out of fashion]
- Source :
- Medecine sciences : M/S. 36(6-7)
- Publication Year :
- 2020
-
Abstract
- A systematic search for non-conventional open reading frames in human DNA reveals a large number of small ORFs encoding peptides generally smaller than 100 amino-acids. These ORFs are transcribed and translated into small proteins, which are demonstrated to have functional significance by bulk CRISPR inactivation. Evidence is also found for bicistronic mRNAs including such a small ORF upstream of a canonical coding sequence. These findings add a new facet to our understanding of biological processes.
Details
- Language :
- French
- ISSN :
- 19585381
- Volume :
- 36
- Issue :
- 6-7
- Database :
- OpenAIRE
- Journal :
- Medecine sciences : M/S
- Accession number :
- edsair.pmid..........49c09f5ce61a0039d334082804d0150c