[Association of small dense low-density lipoprotein cholesterol with H-type hypertension and MTHFR gene polymorphism]

To investigate the expression of small dense low-density lipoprotein cholesterol (sdLDL-C) in patients with H-type hypertension and its association with H-type hypertension and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. The retrospective study method was used,and a total of 207 hospitalized hypertensive patients (76 males and 131 females, aged 40-82 years, median age 66 years) admitted to the Zibo First Hospital from March 2021 to March 2022 were enrolled in this study. The levels of homocysteine (Hcy), sdLDL-C, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglyceride (TG) and lipoprotein (a) [Lp(a)] were measured. The patients were divided into H-type hypertensive group (探讨小而密低密度脂蛋白胆固醇（sdLDL-C）在H型高血压患者中的表达及其与H型高血压和亚甲基四氢叶酸还原酶（MTHFR）基因多态性间的相关性。采用回顾性研究，选择2021年3月至2022年3月在山东省淄博市第一医院诊治的207例住院高血压患者，男76例，女131例，年龄40~82岁、中位数年龄66岁。检测同型半胱氨酸（Hcy）、sdLDL-C、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）、甘油三酯（TG）、脂蛋白（a）［Lp（a）］水平。根据Hcy水平分为H型高血压组（105例，男性40例，女性65例）和非H型高血压组（102例，男性36例，女性66例），检测各组MTHFR C677T多态性，对H型高血压发生相关因素进行logistic回归分析。结果显示，H型高血压组和非H型高血压组血清sdLDL-C水平分别为（0.92±0.31）mmol/L和（0.65±0.28）mmol/L，H型高血压组sdLDL-C水平显著高于非H型高血压组（